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Non-GMO

Non-GMO

Gluten-free

Gluten-free

For vegans

For vegans

Free from major allergens

Free from major allergens

Endotoxin-free

Endotoxin-free

No preservatives

No preservatives

 
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NAD+ Prime

Energy that starts in the cells

We created NAD+ Prime for those who want to support energy and vitality through ingredients naturally linked to cellular metabolism. NAD⁺ is a coenzyme present in every cell of the body and plays an essential role in processes related to energy production. With age, its levels naturally decline, and during periods of a fast-paced lifestyle, the body's demand for NAD⁺ may be even higher, which can be reflected in fatigue and reduced vitality.

The foundation of the NAD+ Prime formula is the bioactive form of nicotinamide riboside (NR-CL) - a form of vitamin B3 that the body uses as a natural precursor for NAD⁺ production directly in the cells. Trimethylglycine (TMG) complements the formula through its role in homocysteine metabolism and supports a balanced metabolic environment.

The formula also includes apigenin, a natural compound associated with supporting a balanced cellular environment, and active vitamin B2, which contributes to normal energy-yielding metabolism and to the reduction of tiredness and fatigue. Together, these ingredients create a thoughtful synergy, supporting natural energy metabolism, cellular vitality and more balanced long-term performance without unnecessary stimulation.

SCIENTIFIC EVIDENCE

Clinical study from 2026 published in iScience demonstrated for the first time that oral supplementation with nicotinamide riboside not only increases NAD+ levels in the blood (with a plateau after approximately 2 weeks), but also measurably increases NAD+ levels in the brain after 4 weeks of use — which is key for neuroprotective effects.

Study: Berven H et al. The NAD-brain pharmacokinetic study of NAD augmentation in blood and brain using oral precursor supplementation. iScience, 2026.
Link: https://pubmed.ncbi.nlm.nih.gov/41858901/

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What makes NAD+ Prime exceptional

NAD+ Prime is built on a thoughtful synergy of ingredients, which together support cellular metabolism and processes related to energy, regeneration, and long-term vitality. At the core of the formula is highly stable NR-CL, included as the primary source for energy processes, complemented by TMG to support a balanced metabolic environment.

The formula is further enhanced by apigenin, which helps the body make the most of its potential. The entire complex is built on the principles of purity, functional synergy, and a sustainable approach to vitality, without unnecessary additives or compromises in composition.

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With regular use of NAD+ Prime, you may gradually notice changes in how you handle everyday strain:

Timeline of NAD+ Prime’s effects on the body

  • Week 1:

    Less fatigue and greater mental freshness.

  • 1st month:

    Better focus and less fatigue after exercise.

  • 3rd month:

    More stable performance and less exhaustion during the day.

  • Month 6 onwards:

    Long-term vitality and inner balance.

The onset and intensity of the effects are individual. Everyone is unique and responds to nutrient supplementation at their own pace, depending on their current condition and lifestyle.

WHAT EXPERTS SAY

NAD+ Prime is formulated around nicotinamide riboside as a precursor to NAD⁺ and is further enhanced with trimethylglycine (betaine), which supports methylation balance, and apigenin, which is being studied in relation to CD38 modulation. This thoughtfully designed formula reflects the current theoretical understanding of NAD⁺ metabolism and its broader biological context. Nicotinamide riboside is associated in clinical research with a growing, though still evolving, body of data on increasing NAD⁺ levels in humans. However, direct health benefits beyond this support remain the subject of further expert investigation.

Dr. Rosmy Barrios, MD – Medical Doctor
Physician specializing in anti-ageing, longevity, and regenerative medicine. Head of the regenerative medicine department.

Who is this supplement intended for?

  • For those who want to support performance, energy, and cellular function

    For those who want to support performance, energy, and cellular function

  • For people over 40 who want to support vitality and regeneration over the long term

    For people over 40 who want to support vitality and regeneration over the long term

  • Managers, entrepreneurs, and anyone under high mental strain

    Managers, entrepreneurs, and anyone under high mental strain

  • For athletes and active individuals who want to support both energy and recovery

    For athletes and active individuals who want to support both energy and recovery

Recommended use

Daily dosage
1–2 capsules daily. Regular use: 1 capsule daily. Intensive use (8–12 weeks): 2 capsules daily.
When to take
In the morning on an empty stomach, with a sufficient amount of water. If taking 2 capsules: morning + early afternoon. Do not take in the late afternoon or evening.
With or without food
Can be taken independently of food. We recommend taking it on an empty stomach for optimal absorption.
Important
Do not exceed the recommended daily dose. After 3–4 months, we recommend a short break of 1–2 weeks.
Storage
Store in a dry, cool place away from direct sunlight. Food supplements are not a substitute for a varied and balanced diet and a healthy lifestyle. Best before and batch number: see packaging.

Warning: If you are taking medication that affects the blood, thyroid, or immune system, consult your doctor before use. If you are pregnant or breastfeeding, consult your doctor.

Key benefits

  • Cellular energy support

    Supports energy metabolism at the cellular level and helps the body use its own energy more efficiently.

    • Nicotinamide riboside chloride (NR-CL)
    • Vitamin B2 (riboflavin-5′-phosphate)
  • Sustainable vitality without unnecessary exhaustion

    Helps the body cope with the demands of a busy day and contributes to reducing tiredness and fatigue.

    • Trimethylglycine (TMG)
    • Vitamin B2
  • Cell protection during increased strain

    Helps maintain inner balance and contributes to the protection of cells from oxidative stress during both physical and mental strain.

    • Nicotinamide riboside chloride (NR-CL)
    • Vitamin B2 (riboflavin-5′-phosphate)
    • Apigenin

Thoughtful combinations for long-term vitality

By combining multiple NOZONO formulas, you can support key areas of health in a broader context and benefit from their synergistic effect. Choose a bundle according to your priorities, needs, and pace of life.
4.7
NOZONO Signature System

Complete system for long-term vitality

€531,95
NOZONO Signature System
4.8
NAD+ Sustain Duo

Recovery day and night

€162,95
NAD+ Sustain Duo
4.6
Genome Renewal Duo

Support for cellular integrity over time

€169,95
Genome Renewal Duo

Ingredients

NAD+ Prime is built on carefully selected active ingredients that support cellular processes associated with energy, regeneration, and mental performance. Its formula was created to fit into a thoughtful and long-term sustainable approach to vitality and everyday performance. Suitable for vegetarians.

The amount of active ingredients is stated for the recommended daily dose of 2 capsules.

Nicotinamide riboside chloride (NR-Cl)

Nicotinamide riboside chloride (NR-Cl)

Content: 300 mg, NRV: Not established

  • Supports energy production in cells
  • Contributes to vitality and overall balance
  • Helps you better manage a demanding pace of life
Betaine

Betaine

Content: 760 mg, NRV: Not established

  • Supports natural metabolic balance
  • Contributes to the proper functioning of internal processes
  • Ideal for safe, long-term use
Chamomile extract

Chamomile extract

Content: 100 mg, RHP: Not specified

  • Supports the stability of cellular processes
  • Contributes to the efficient use of cellular potential
  • Natural antioxidant from chamomile
Vitamin B2

Vitamin B2

Content: 10 mg, NRV: 714%

  • Contributes to normal energy-yielding metabolism
  • Helps protect cells from oxidative stress
  • Helps reduce tiredness and fatigue
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Frequently Asked Questions

Can I combine NAD+ Prime with other food supplements?

Yes, in most cases, NAD+ Prime can be taken alongside standard multivitamins, minerals, and adaptogens. The formula is designed not to interfere with the effects of other supplements, but rather to complement a broader wellness routine naturally. If your supplementation plan is more comprehensive, we recommend leaving a gap of 1 to 2 hours between individual products.

Is NAD+ Prime suitable for long-term use?

Yes, NAD+ Prime is also formulated for long-term use. The formula includes TMG, which supports the methylation cycle and contributes to maintaining normal homocysteine levels. The formula is suitable for continuous use, contains no synthetic stimulants, and to fully develop its potential, it is ideal to take it for at least 2 to 3 months.

Does NAD+ Prime contain caffeine or stimulants?

No, NAD+ Prime is completely free of caffeine and other stimulants. Its effect is based on supporting the mitochondria and the NAD⁺ cycle — natural processes linked to cellular energy, rather than external stimulation. As a result, it offers a more refined form of energy support without jitteriness and without unnecessary strain on the body.

Can I take the product in the evening as well?

In some individuals, NAD+ Prime may feel gently activating, as it supports cellular energy and related metabolic processes. To fit best into your daily rhythm, we therefore recommend taking the last capsule no later than 16:00. If taken later, more sensitive individuals may experience delayed sleep onset.

Is the product suitable for women?

Yes, NAD+ Prime is formulated as a versatile and thoughtfully balanced formula that is also suitable for women. It may support energy, mental focus, and resilience to everyday demands.

However, during pregnancy and while breastfeeding, it is always advisable to consult a doctor before use.

When will I feel the effect?

Some users may notice the first changes in energy levels within as little as 5 to 7 days of use. The fuller development of the effect at the cellular level usually appears after 3 to 4 weeks of regular use. Over the longer term, the formula may contribute to greater resilience to fatigue and more balanced performance.

Is it necessary to take breaks while using it?

Regular breaks in use are not necessary, as the ingredients in the formula are naturally connected to NAD⁺ metabolism and methylation processes. However, as part of a well-balanced long-term routine, we recommend taking a short break after 3 to 4 months, usually for 1 to 2 weeks. This gives your body the space to maintain a stable and sustainable long-term rhythm.

Straightforward about what matters most

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