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NAD+ Prime

Food supplement to support NAD+, cellular energy, and long-term vitality, 60 capsules

| 17 Total number of reviews
NAD+ Prime
NAD+ Prime
NAD+ Prime
NAD+ Prime
NAD+ Prime

NAD+ Prime

Food supplement to support NAD+, cellular energy, and long-term vitality, 60 capsules

| 17 Total number of reviews

Advanced NADโบ support and mitochondrial energy for regeneration and cellular performance.

  • Increases NAD+ levels in the body
  • Supports mitochondrial energy production and metabolism
  • Activates sirtuin proteins associated with healthy ageing
  • Protects cells against oxidative burden
  • Supports DNA repair and the maintenance of epigenetic stability
  • Protects cells against oxidative stress
  • Supports recovery and physical and mental vitality
  • Helps maintain skin health, hydration and renewal
  • Supports the circadian rhythm and cellular resilience
  • Monthly supply: 60 capsules | 30 daily servings
  • Every NOZONO product is stored in a luxurious glass jar

In stock. Ships immediately.
 
Non-GMO

Non-GMO

Gluten-free

Gluten-free

For vegans

For vegans

Free from major allergens

Free from major allergens

Endotoxin-free

Endotoxin-free

No preservatives

No preservatives

 
Reviews
About the product Key benefits Bundles Ingredients Frequently asked questions
4.8
17 reviews for this product
All reviews
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NAD+ Prime

Cellular energy and regeneration start with NAD+

NAD+ is not just another molecule in the body. It is the fundamental energy and repair โ€œcurrencyโ€ of cells, without which mitochondria cannot efficiently convert nutrients into ATP โ€“ the energy needed for movement, focus, recovery, and everyday functioning. At the same time, NAD+ supports sirtuin activity, DNA repair, gene regulation, and the ability of cells to respond to metabolic stress.

NOZONO NAD+ Prime is a premium cellular formula designed to support NAD+ levels, mitochondrial energy, sirtuin pathways, and natural repair processes.ย It does not work as a short-term energy stimulant. It focuses directly on the cellular mechanisms that influence vitality, recovery, and the way the body ages over time.

This thoughtfully designed formula combinesย nicotinamide riboside chloride (NR-Cl), betaine TMG, chamomile extract as a source of apigenin, and vitamin B2. Nicotinamide riboside serves as a direct precursor to NAD+, TMG supports methylation balance, apigenin helps protect available NAD+ from excessive consumption, and vitamin B2 contributes to normal energy metabolism and the protection of cells from oxidative stress.

With age, long-term stress, lack of sleep, and high metabolic load, NAD+ levels naturally decline. Cells may then produce energy less efficiently, recover more slowly, and respond less effectively to everyday strain.

NAD+ Prime provides the body with the key substances needed for the production and maintenance of NAD+. In this way, it supports cellular energy, mitochondrial performance, mental freshness, physical resilience, and long-term vitality.

It is created for people who do not want to address only momentary fatigue, but want to actively support the very foundations of energy and recovery at the cellular level.

NAD+ Prime does not only provide energy for today. It supports the molecule on which the energy, renewal, and long-term condition of your cells depend.

SCIENTIFIC EVIDENCE

A clinical study from 2026 published in iScience demonstrated for the first time that oral supplementation with nicotinamide riboside not only increases NAD+ levels in the blood (with a plateau after approximately 2 weeks), but also measurably increases NAD+ levels in the brain after 4 weeks of use โ€” which is key for neuroprotective effects.

Study: Berven H et al. The NAD-brain pharmacokinetic study of NAD augmentation in blood and brain using oral precursor supplementation. iScience, 2026.
Link: https://pubmed.ncbi.nlm.nih.gov/41858901/
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How NAD+ Prime works

NAD+ Prime supports key processes linked to cellular energy, renewal, and healthy ageing. Its formula helps replenish NAD+, support mitochondria, sirtuin pathways, methylation balance, and the protection of cells against oxidative stress.

1. Increases NAD+ levels

Nicotinamide riboside is a direct precursor to NAD+, which cells use to restore its levels. Greater NAD+ availability provides the foundation for more efficient energy production, metabolism, and cellular renewal.

2. Supports mitochondrial energy

NAD+ is essential for ATP production in the mitochondria. NAD+ Prime therefore supports steady cellular performance, physical endurance, mental clarity, and recovery without caffeine or nervous system stimulation.

3. Activates sirtuins and repair processes

Sirtuins require NAD+ to function. Supporting its levels helps activate processes linked to cellular resilience, metabolic regulation, DNA repair, and the maintenance of epigenetic stability.

4. Protects cells against oxidative stress

Vitamin B2 contributes to normal energy-yielding metabolism and the protection of cells from oxidative stress. At the same time, NAD+ supports the cellsโ€™ natural defence and renewal mechanisms.

5. Supports methylation and circadian balance

Betaine TMG provides methyl groups important for methylation processes and homocysteine metabolism. NAD+ and sirtuins are also involved in circadian rhythm, cellular renewal, and processes associated with healthy ageing.

NAD+ Prime supports the very foundation of cellular energy, renewal, and long-term vitality โ€“ the NAD+ molecule, without which cells cannot function at their best.

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With regular use of NAD+ Prime, you may gradually notice changes in how you handle everyday strain:

Timeline of NAD+ Primeโ€™s effects on the body

  • Week 1:

    You may begin to notice greater mental freshness, less fatigue, more stable energy, and a quicker return to performance after a demanding day.

  • Month 1:

    NAD+ levels may rise more steadily, supporting better focus, recovery, mitochondrial energy, and resilience to stress.

  • 3rd month:

    Longer-term support of sirtuins, DNA repair, and energy metabolism may contribute to more stable physical and mental performance and less fatigue.

  • Month 6 onwards:

    Regular NAD+ supplementation supports long-term cellular vitality, metabolic balance, regeneration, and healthy ageing mechanisms.

WHAT DO THE EXPERTS SAY

NAD+ Prime is formulated around nicotinamide riboside as a precursor to NADโบ and is further enhanced with trimethylglycine (betaine), which supports methylation balance, and apigenin, which is being studied in relation to CD38 modulation. This thoughtfully designed formula reflects the current theoretical understanding of NADโบ metabolism and its broader biological context. Nicotinamide riboside is associated in clinical research with a growing, though still evolving, body of data on increasing NADโบ levels in humans. However, direct health benefits beyond this support remain the subject of further expert investigation.

Dr. Rosmy Barrios, MD โ€“ Medical Doctor
Dr. Rosmy Barrios, MD โ€“ Medical Doctor
Physician specializing in anti-aging, longevity, and regenerative medicine. Head of the regenerative medicine department.

Who is this supplement intended for?

  • For those who want to support performance, energy, and cellular function

    For those who want to support performance, energy, and cellular function

  • For people over 40 who want to support vitality and regeneration over the long term

    For people over 40 who want to support vitality and regeneration over the long term

  • Managers, entrepreneurs, and anyone under high mental strain

    Managers, entrepreneurs, and anyone under high mental strain

  • For athletes and active individuals who want to support both energy and recovery

    For athletes and active individuals who want to support both energy and recovery

Recommended use

Daily dosage
1โ€“2 capsules daily. Regular use: 1 capsule daily. Intensive use (8โ€“12 weeks): 2 capsules daily.
When to take
In the morning on an empty stomach, with a sufficient amount of water. If taking 2 capsules: morning + early afternoon. Do not take in the late afternoon or evening.
With or without food
Can be taken independently of food. We recommend taking it on an empty stomach for optimal absorption.
Important
Do not exceed the recommended daily dose. After 3โ€“4 months, we recommend a short break of 1โ€“2 weeks.
Storage
Store in a dry, cool place away from direct sunlight. Food supplements are not a substitute for a varied and balanced diet and a healthy lifestyle. Best before and batch number: see packaging.

Warning: If you are taking medication that affects the blood, thyroid, or immune system, consult your doctor before use. If you are pregnant or breastfeeding, consult your doctor.

Key benefits

  • Cellular energy support

    Cellular energy support

    Supports energy metabolism at the cellular level and helps the body use its own energy more efficiently.

    • Nicotinamide riboside chloride (NR-CL)
    • Vitamin B2 (riboflavin-5โ€ฒ-phosphate)
  • Sustainable vitality without unnecessary exhaustion

    Sustainable vitality without unnecessary exhaustion

    Helps the body cope with the demands of a busy day and contributes to reducing tiredness and fatigue.

    • Trimethylglycine (TMG)
    • Vitamin B2
Key benefits
  • Cell protection during increased strain

    Cell protection during increased strain

    Helps maintain inner balance and contributes to the protection of cells from oxidative stress during both physical and mental strain.

    • Nicotinamide riboside chloride (NR-CL)
    • Vitamin B2 (riboflavin-5โ€ฒ-phosphate)
    • Apigenin

Thoughtful combinations for long-term vitality

By combining multiple NOZONO formulas, you can support key areas of health in a broader context and benefit from their synergistic effect. Choose a bundle according to your priorities, needs, and pace of life.
4.7
NOZONO Signature System

Complete longevity system for energy, recovery, mind, and immunity

โ‚ฌ454,95
NOZONO Signature System
4.7
NAD+ Sustain Duo

Daily NAD+ support. Night-time recovery. One comprehensive longevity routine

โ‚ฌ152,95
NAD+ Sustain Duo
4.6
Genome Renewal Duo

Support for NAD+, cellular energy, and long-term vitality

โ‚ฌ163,95
Genome Renewal Duo
Discover all bundles

Ingredients

NAD+ Prime is built on carefully selected active ingredients that support cellular processes associated with energy, regeneration, and mental performance. Its formula was created to fit into a thoughtful and long-term sustainable approach to vitality and everyday performance. Suitable for vegetarians.

The amount of active ingredients is stated for the recommended daily dose of 2 capsules.

Nicotinamide riboside chloride (NR-Cl)

Nicotinamide riboside chloride (NR-Cl)

Content: 300 mg, NRV: Not established

  • Supports energy production in cells
  • Contributes to vitality and overall balance
  • Helps you better manage a demanding pace of life
Betaine

Betaine

Content: 760 mg, NRV: Not established

  • Supports natural metabolic balance
  • Contributes to the proper functioning of internal processes
  • Ideal for safe, long-term use
Chamomile extract

Chamomile extract

Content: 60 mg, NRV: Not established

  • Supports the stability of cellular processes
  • Contributes to the efficient use of cellular potential
  • Natural antioxidant from chamomile
Vitamin B2

Vitamin B2

Content: 10 mg, NRV: 714%

  • Contributes to normal energy-yielding metabolism
  • Helps protect cells from oxidative stress
  • Helps reduce tiredness and fatigue
Show all 17 reviews

Frequently Asked Questions

Can I combine NAD+ Prime with other food supplements?

Yes, in most cases, NAD+ Prime can be taken alongside standard multivitamins, minerals, and adaptogens. The formula is designed not to interfere with the effects of other supplements, but rather to complement a broader wellness routine naturally. If your supplementation plan is more comprehensive, we recommend leaving a gap of 1 to 2 hours between individual products.

Is NAD+ Prime suitable for long-term use?

Yes, NAD+ Prime is also formulated for long-term use. The formula includes TMG, which supports the methylation cycle and contributes to maintaining normal homocysteine levels. The formula is suitable for continuous use, contains no synthetic stimulants, and to fully develop its potential, it is ideal to take it for at least 2 to 3 months.

Does NAD+ Prime contain caffeine or stimulants?

No, NAD+ Prime is completely free of caffeine and other stimulants. Its effect is based on supporting the mitochondria and the NADโบ cycle โ€” natural processes linked to cellular energy, rather than external stimulation. As a result, it offers a more refined form of energy support without jitteriness and without unnecessary strain on the body.

Can I take the product in the evening as well?

In some individuals, NAD+ Prime may feel gently activating, as it supports cellular energy and related metabolic processes. To fit best into your daily rhythm, we therefore recommend taking the last capsule no later than 16:00. If taken later, more sensitive individuals may experience delayed sleep onset.

Is the product suitable for women?

Yes, NAD+ Prime is formulated as a versatile and thoughtfully balanced formula that is also suitable for women. It may support energy, mental focus, and resilience to everyday demands.

However, during pregnancy and while breastfeeding, it is always advisable to consult a doctor before use.

When will I feel the effect?

Some users may notice the first changes in energy levels within as little as 5 to 7 days of use. The fuller development of the effect at the cellular level usually appears after 3 to 4 weeks of regular use. Over the longer term, the formula may contribute to greater resilience to fatigue and more balanced performance.

Is it necessary to take breaks while using it?

Regular breaks in use are not necessary, as the ingredients in the formula are naturally connected to NADโบ metabolism and methylation processes. However, as part of a well-balanced long-term routine, we recommend taking a short break after 3 to 4 months, usually for 1 to 2 weeks. This gives your body the space to maintain a stable and sustainable long-term rhythm.

Clinical Studies and Research

Riboflavin: essential for oxidative phosphorylation in the mitochondrial respiratory chain and the prevention of fatigue ยท Journal of Translational Genetics and Genomics ยท 2020
NADPARK study: nicotinamide riboside in the brains of patients with Parkinsonโ€™s disease โ€” double-blind, placebo-controlled phase I study ยท 30 patients, 1000 mg NR/day for 30 days
Repeated doses of NRPT (nicotinamide riboside and pterostilbene) safely and sustainably increase NAD+ levels in humans ยท PubMed ยท PMID: 29184669
Randomized study: 6 g of betaine/day for 12 weeks during a calorie-restricted diet โ€” significant reduction in homocysteine ยท PubMed ยท PMID: 12399266
TMG meta-analysis: betaine at a dose of 4โ€“6 g/day reduces plasma homocysteine by approximately 5โ€“20% ยท PMC ยท PMC3610948
NR supplementation in older men: a randomized crossover study โ€” increased NAD+ metabolites in muscle and changes in mitochondrial gene expression ยท Cell Reports ยท 2019
Review: Betaine Metabolism, the Role of a Methyl Donor, Effects on Cardiometabolic Risk, and Interactions with B12/Folate ยท Molecules (MDPI) ยท 2023
The flavonoid apigenin is an inhibitor of the CD38 NADase โ€” the key paper by Escande et al.: inhibition of CD38 by apigenin increased NAD+ in vitro and in vivo ยท PMC ยท 2013
CD38 inhibition in obese animals: pharmacological inhibition improved glucose tolerance and insulin sensitivity; apigenin identified as a natural CD38 inhibitor ยท Cell Metabolism ยท 2018
Apigenin, CD38, NAD+ and healthy aging โ€” high CD38 activity and low NAD+ are associated with aging and metabolic diseases ยท Frontiers in Nutrition ยท 2024
2024 Review: The Role of Riboflavin in Energy Metabolism, Mitochondrial Function and Immunity; Essential for the Formation of FAD/FMN in Oxidative Phosphorylation ยท MDPI ยท 2024
B vitamins including riboflavin and migraine: high-dose riboflavin (typically 400 mg/day) reduces migraine frequency thanks to improved mitochondrial energetics ยท ScienceDirect ยท 2018
Mechanisms of Riboflavin and Clinical Benefits - adequate riboflavin is important for redox processes and the metabolism of carbohydrates, fats, and proteins ยท Nature ยท npj Biofilms and Microbiomes ยท 2024
Oral NR supplementation at a dose of 500โ€“1000 mg/day significantly increases NAD+ levels in blood and tissues, safely even with long-term use ยท PubMed ยท PMID: 29184669
Increased NAD+ is associated with improved mitochondrial function and support for energy metabolism ยท ScienceDirect ยท 2025

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